Fibroblasts proliferation and ECM synthesis stimulation

This questionnaire is made for you to make sure you understood properly the 2 studies sent last week and remember the key information. It will also be helpful for us to see which elements might need to be seen in a coming training session.

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Question 1

Merci d'entrer ici votre pseudonyme

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Question 2

What is the role of fibroblasts?

Fibroblasts play a major role in the granulation phase, producing the keratinocytes.

Fibroblasts play a major role in the epithelialization phase, producing the keratinocytes.

Fibroblasts play a major role in the granulation phase, producing the new ECM (extra-cellular matrix).

Fibroblasts play a major role in the epithelialization phase, producing the new ECM (extra-cellular matrix).

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Question 3

Within the following proposals, select the conclusion(s) that have been proven by the study \"Stimulation of the proliferation of human dermal fibroblasts in vitro by a lipidocoilloïd dressing\":

At 48h, stimulation of the proliferation of fibroblasts with UrgoTul was up to 70% greater than in the controls (45% greater in average).

UrgoTul stimulated the synthesis of collagen by 80%.

Mepitel is cytotoxic for fibroblasts.

Greazy gauzes are cytotoxic for fibroblasts.

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Question 4

Within the following proposals, select the one(s) that is/are correct about the ECM (extra-cellular matrix):

Components of the ECM include: collagen, fibronectin, elastin, hyaluronic acid and glycosaminoglycans (GAGs).

Most ECM’s components originate from fibroblasts.

The ECM gives the dermis its definitive structure, flexibility and strength.

The ECM gives the epidermis its definitive structure, flexibility and strength.

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Question 5

In the in vitro study on the effect of UrgoTul on the stimulation of the extra-cellular matrix synthesis, the production/release of soluble (pro-)collagen I was greater with UrgoTul than in the control by:

45 %

53 %

70 %

80 %

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Question 6

In the in vitro study on the effect of UrgoTul on the stimulation of the extra-cellular matrix synthesis, the synthesis of hyaluronic acid was greater with UrgoTul than in the control by:

45 %

53 %

70 %

80 %

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